Why is it that some people respond better to treatment for Lyme disease than others. Is it possible they may have had a second infection they were not aware of... ? According to this study, certain patients diagnosed with post-Lyme disease syndrome have antibodies that suggest they carried the infection for an unusually long time. References : Chandra A. et al. Clin. Immunol. http://dx.doi.org/10.1016/j.clim.2011.06.005 (2011).